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            <h1 id="seo-header">实用免疫学（十一）白细胞分化番外篇一：胚系基因重排</h1>
            
            
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                <h2 id="胚系基因的结构"><a href="#胚系基因的结构" class="headerlink" title="胚系基因的结构"></a>胚系基因的结构</h2><h3 id="TCR胚系基因"><a href="#TCR胚系基因" class="headerlink" title="TCR胚系基因"></a>TCR胚系基因</h3><p><img src="https://img-cdn.limour.top/blog/20220323212625.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h3 id="免疫球蛋白胚系基因"><a href="#免疫球蛋白胚系基因" class="headerlink" title="免疫球蛋白胚系基因"></a>免疫球蛋白胚系基因</h3><p><img src="https://img-cdn.limour.top/blog/20220323211316.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h2 id="胚系基因重排"><a href="#胚系基因重排" class="headerlink" title="胚系基因重排"></a>胚系基因重排</h2><h3 id="TCR基因重排"><a href="#TCR基因重排" class="headerlink" title="TCR基因重排"></a>TCR基因重排</h3><p><img src="https://img-cdn.limour.top/blog/20220323213508.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h3 id="免疫球蛋白基因重排"><a href="#免疫球蛋白基因重排" class="headerlink" title="免疫球蛋白基因重排"></a>免疫球蛋白基因重排</h3><p><img src="https://img-cdn.limour.top/blog/20220323213649.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h2 id="胚系基因重组与连接"><a href="#胚系基因重组与连接" class="headerlink" title="胚系基因重组与连接"></a>胚系基因重组与连接</h2><h3 id="RSS（重组信号序列）"><a href="#RSS（重组信号序列）" class="headerlink" title="RSS（重组信号序列）"></a>RSS（重组信号序列）</h3><ul>
<li>一些位于Ig 和 TCR可变区基因片段外显子旁侧、与可变区基因片段重排有关的 DNA序列</li>
<li>RSS包括一个高度保守的、具有回文结构的7核苷酸序列（heptamer，CACAGTG），总是紧邻V、D和J基因的外显子</li>
<li>两者之间、非保守的 12或 23碱基对（bp）间隔序列（space）</li>
<li>一个高度保守的、富含 A（腺嘌呤核苷）的9核苷酸序列（nonamer，ACAAAAACC）;</li>
</ul>
<p><img src="https://img-cdn.limour.top/blog/20220323215109.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h3 id="12-23规则"><a href="#12-23规则" class="headerlink" title="12&#x2F;23规则"></a>12&#x2F;23规则</h3><ul>
<li>12&#x2F;23规则：可变区基因片段之间的重排往往发生于同一条染色体，遵循12&#x2F;23规则<br>即一侧为12 bp 间隔序列RSS的基因片段，只能与一侧为 23 bp 间隔序列RSS 的基因片段进行组合。</li>
</ul>
<p><img src="https://img-cdn.limour.top/blog/20220323215323.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h3 id="VJ重组"><a href="#VJ重组" class="headerlink" title="VJ重组"></a>VJ重组</h3><p><a target="_blank" rel="noopener" href="https://zhuanlan.zhihu.com/p/32448578"><img src="https://img-cdn.limour.top/blog/20220323220929.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></a></p>
<p><img src="https://img-cdn.limour.top/blog/20220323221819.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<p><img src="https://img-cdn.limour.top/blog/20220323221635.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<h2 id="TCR与BCR多样性比较"><a href="#TCR与BCR多样性比较" class="headerlink" title="TCR与BCR多样性比较"></a>TCR与BCR多样性比较</h2><p><img src="https://img-cdn.limour.top/blog/20220323222812.png" srcset="https://jscdn.limour.top/gh/Limour-dev/Sakurairo_Vision/load_svg/inload.svg" lazyload></p>
<p>由于TCRα链含有较多的J基因片段，且100%发生PN核苷酸插入，因此连接多样性远大于BCR</p>

                
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