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- 适应性免疫的激活离不开抗原。抗原是能被TCR和BCR特异性识别,促使抗原特异性T、B细胞活化、增殖和分化,产生免疫应答效应产物,并与之结合,进而发挥适应性免疫应答效应的物质。其有两个重要且独立的特性:免疫原性和抗原性(免疫反应性)。 免疫原性:诱导适应性免疫应答的能力 抗原性:与免疫效应产物结合的能力 不具有免疫原性的小分子半抗原可以是大分子蛋白质载体共价结合获得免疫原性。(青霉素与血浆蛋白、
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- 实用免疫学(七)适应性免疫:体液免疫
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- 环境中的病原体侵入生物机体后,胞外菌寄居在宿主的细胞外组织液、淋巴液和血液等体液中。侵入的病原体会刺激特异性B细胞活化并分化为浆细胞。根据B细胞对Ag的反应,将Ag分为TI-Ag(胸腺非依赖性抗原)和TD-Ag(胸腺依赖性抗原)。活化的B细胞通过产生抗体来发挥效应。 TI-Ag该类抗原刺激机体产生抗体无需T细胞的辅助,可以分为TI-1Ag和TI-2Ag。 TI-1Ag 既有抗原表位又有丝裂原性
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